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KMID : 0893420150160030325
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Journal of Veterinary Science
2015 Volume.16 No. 3 p.325 ~ p.331
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The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity
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Zhou Guang Fang
Liu Qing Tao
Zhou Bin
Qiu Ya Feng
Liu Xiao Dong
Ma Zhi Yong
Feng Xiu Li
Cao Rui Bing
Chen Pu Yan
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Abstract
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The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profiles of hybridoma cells treated with BSP-II were evaluated. Pathway analysis showed that regulated genes were involved in cytokine-cytokine receptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that BSP-II reduced tumor cells proliferation and stimulated p53 expression. These results indicate potential mechanisms underlying the effects of the humoral immune system on immune induction, including antitumor activities. Our study has provided a novel insight into immunotherapeutic strategies for treating human tumors.
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KEYWORD
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bursal septpeptide II, humoral immune system, pathway analysis, tumor suppressor p53
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