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KMID : 0893420150160040501
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Journal of Veterinary Science
2015 Volume.16 No. 4 p.501 ~ p.507
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Isolation and immunomodulatory activity of bursal peptide, a novel bursal peptide from the chicken bursa of Fabricius
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Liu Xiao Dong
Qian Yingjuan
Jung Yong-Sam
Chen Pu Yan
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Abstract
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The bursa of Fabricius (BF), which is unique to birds, serves as the central humoral immune organ and plays a significant role in B lymphocyte differentiation. In this study, a new bursal peptide (BP-IV) was isolated from BF, which promoted colony-forming unit pre-B formation and regulated B cell differentiation. BP-IV also exerted immunomodulatory effects on antigen-specific immune responses via both humoral and cellular immunity in chicken and mice that had been immunized with inactivated avian influenza virus (AIV; H9N2 subtype), including enhancing AIV-specific antibody and cytokine production. The results of this study provided novel insights into the use of a potential candidate reagent for B cell development and future immuno-pharmacological use.
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KEYWORD
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B cell development, bursal peptide, immunomodulatory experiment, immunomodulatory function
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