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KMID : 0893420160170010097
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Journal of Veterinary Science
2016 Volume.17 No. 1 p.97 ~ p.102
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Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats
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Chung Hyo-Jin
Chung Wook-Hun
Lee Jae-Hoon
Chung Dai-Jung
Yang Wo-Jong
Lee A-Jin
Choi Chi-Bong
Chang Hwa-Seok
Kim Dae-Hyun
Suh Hyun-Jung
Lee Dong-Hun
Hwang Soo-Han
Do Sun-Hee
Kim Hwi-Yool
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Abstract
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We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.
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KEYWORD
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brain-derived neurotrophic factor, nerve growth factor, neurotrophic factor, neurotrophin-3, spinal cord injury
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