KMID : 0893420160170010111
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Journal of Veterinary Science 2016 Volume.17 No. 1 p.111 ~ p.113
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Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs
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Ponchon Tamara
Merlo Mariana Lopez Faya Marcela Priotto Marcelo Barbeito Claudio Gobello Cristina
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Abstract
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To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per ¥ìm2 of endometrium nor in the height of the uterine epithelium.
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KEYWORD
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canid, contraception, endocrine disruption, genital tract, neonatal
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