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KMID : 0893420160170010123
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Journal of Veterinary Science
2016 Volume.17 No. 1 p.123 ~ p.126
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Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs
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Kim Yong-Sun
Lee Seung-Hoon
Kim Wan-Hee
Kweon Oh-Kyeong
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Abstract
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Thirty-four dogs with no deep pain perception due to acute thoracolumbar intervertebral disc disease underwent decompression surgery within 1 week of diagnosis. All dogs underwent hemilaminectomy. Adipose derived mesenchymal stem cells (AD-MSCs) were transplanted into the injured spinal cord parenchyma for the AD-MSCs transplant dogs. Long-term outcome was evaluated at the end of the follow-up period (> 6 months). AD-MSCs combination treatment showed better recovery outcomes compared to decompression surgery alone. These results indicate that this stem cell therapy is a potential therapeutic strategy to overcome the limitations of treatment for spinal cord injury in clinical medicine.
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KEYWORD
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adipose derived mesenchymal stem cells, decompression surgery, dog, intervertebral disc disease
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