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KMID : 0893420160170030431
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Journal of Veterinary Science
2016 Volume.17 No. 3 p.431 ~ p.433
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Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs
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Ahn Jin-Ok
Li Qiang
Lee Young-Heun
Han Sei-Myoung
Hwang Cheol-Yong
Youn Hwa-Young
Chung Jin-Young
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Abstract
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Seventeen dogs were treated with L-ornithin-L-aspartate (LOLA; experimental group). Three dogs were treated with lactulose recognized therapy (control group). Following LOLA administration, 15 dogs experienced a significant decrease in ammonia level (p < 0.05) and showed clinical signs of improvement. However, there were no clinical signs of improvement in two dogs, even though the ammonia level decreased. Conversely, the clinical signs of the control group also improved and the ammonia level decreased, although these changes were not significant (p > 0.05). These results suggest that LOLA is an effective drug to treat hyperammonemia in veterinary medicine.
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KEYWORD
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L-ornithin-L-aspartate, dogs, hepatic encephalopathy, hyperammonemia
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