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KMID : 0893420170180020257
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Journal of Veterinary Science
2017 Volume.18 No. 2 p.257 ~ p.260
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Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor
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Hwang Ya-Won
Kim Dong-Wook
Chang Dong-Woo
Ahn Byeong-Woo
Kim Yun-Bae
Kim Gon-Hyung
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Abstract
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This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared approximately two weeks after 5-FC administration. Thoracic radiographs revealed a reduced number of lung nodules and decreased nodule size. However, there were no significant antitumor effects on primary lesions in abdominal organs. In conclusion, human NSC/5-FC prodrug therapy can secure patient quality of life with the same or more therapeutic effects and fewer side effects than other recommended chemotherapies.
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KEYWORD
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flucytosine, gene therapy, metastatic lung tumor, neural stem cells
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