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KMID : 0893420180190010021
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Journal of Veterinary Science
2018 Volume.19 No. 1 p.21 ~ p.26
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Coactosin-like protein 1 inhibits neuronal migration during mouse corticogenesis
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Li Guohong
Yin Yupeng
Chen Jiong
Fan Yanle
Ma Juhong
Huang Yingxue
Chen Chen
Dai Pengxiu
Chen Shulin
Zhao Shanting
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Abstract
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Coactosin-like protein 1 (Cotl1), a member of the actin-depolymerizing factor (ADF)/cofilin family, was first purified from a soluble fraction of Dictyostelium discoideum cells. Neuronal migration requires cytoskeletal remodeling and actin regulation. Although Cotl1 strongly binds to F-actin, the role of Cotl1 in neuronal migration remains undescribed. In this study, we revealed that Cotl1 overexpression impaired migrationof both early- and late-born neurons during mouse corticogenesis. Moreover, Cotl1 overexpression delayed, rather than blocked, neuronal migration in late-born neurons. Cotl1 expression disturbed the morphology of migrating neurons, lengthening the leading processes. This study is the first to investigate the function of Cotl1, and the results indicate that Cotl1 is involved in the regulation of neuronal migration and morphogenesis.
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KEYWORD
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Cotl1 protein, actins, in utero electroporation, neuronal migration
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