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KMID : 0893420180190030472
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Journal of Veterinary Science
2018 Volume.19 No. 3 p.472 ~ p.476
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Double filtration plasmapheresis in the treatment of hyperproteinemia in dogs affected by Leishmania infantum
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Perondi Francesca
Brovida Claudio
Ceccherini Gianila
Guidi Grazia
Lippi Ilaria
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Abstract
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Three dogs were evaluated for severe hyperproteinemia and hyperglobulinemia secondary to Leishmania infantum. Double filtration plasmapheresis (DFPP) was performed in two dogs at days 1, 2, and 6 after presentation. The third dog received DFPP at days 1 and 3 after presentation and eleven hemodialysis treatments. Significant reduction in serum total protein (p ＜ 0.0001), alpha-1 (p = 0.023), alpha-2 (p = 0.018), gamma globulins (p = 0.0105), and a significant increase in albumin/globulin ratio (p = 0.0018) were found. DFPP may be a promising therapeutic technique for rapid resolution of signs of hyperproteinemia in dogs affected by L. infantum.
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KEYWORD
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Leishmania infantum, dogs, double filtration plasmapheresis, hyperproteinemia
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