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KMID : 0893420180190060788
Journal of Veterinary Science
2018 Volume.19 No. 6 p.788 ~ p.797
Synergistic effect of ribavirin and vaccine for protection during early infection stage of foot-and-mouth disease
Choi Joo-Hyung

Jeong Kwi-Wan
Kim Su-Mi
Ko Mi-Kyeong
You Su-Hwa
Lyoo Young-S.
Kim Byoung-Han
Ku Jin-Mo
Park Jong-Hyeon
Abstract
In many countries, vaccines are used for the prevention of foot-and-mouth disease (FMD). However, because there is no protection against FMD immediately after vaccination, research and development on antiviral agents is being conducted to induce protection until immunological competence is produced. This study tested whether well-known chemicals used as RNA virus treatment agents had inhibitory effects on FMD viruses (FMDVs) and demonstrated that ribavirin showed antiviral effects against FMDV in vitro/in vivo. In addition, it was observed that combining the administration of the antiviral agents orally and complementary therapy with vaccines synergistically enhanced antiviral activity and preserved the survival rate and body weight in the experimental animals. Antiviral agents mixed with an adjuvant were inoculated intramuscularly along with the vaccines, thereby inhibiting virus replication after injection and verifying that it was possible to induce early protection against viral infection prior to immunity being achieved through the vaccine. Finally, pigs treated with antiviral agents and vaccines showed no clinical signs and had low virus excretion. Based on these results, it is expected that this combined approach could be a therapeutic and preventive treatment for early protection against FMD.
KEYWORD
foot-and-mouth disease, ribavirin, vaccine
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