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KMID : 0893420200210030043
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Journal of Veterinary Science
2020 Volume.21 No. 3 p.43 ~ p.43
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New genotype classification and molecular characterization of canine and feline parvoviruses
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Chung Hee-Chun
Kim Sung-Jae
Nguyen Van Giap
Shin Sook
Kim Jae-Young
Lim Suk-Kyung
Park Yong-Ho
Park Bong-Kyun
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Abstract
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Background: Canine parvovirus (CPV) and feline panleukopenia (FPV) cause severe intestinal disease and leukopenia.
Objectives: In Korea, there have been a few studies on Korean FPV and CPV-2 strains. We attempted to investigate several genetic properties of FPV and CPV-2.
Methods: Several FPV and CPV sequences from around world were analyzed by Bayesian phylo-geographical analysis.
Results: The parvoviruses strains were newly classified into FPV, CPV 2-I, CPV 2-II, and CPV 2-III genotypes. In the strains isolated in this study, Gigucheon, Rara and Jun belong to the FPV, while Rachi strain belong to CPV 2-III. With respect to CPV type 2, the new genotypes are inconsistent with the previous genotype classifications (CPV-2a, -2b, and -2c). The root of CPV-I strains were inferred to be originated from a USA strain, while the CPV-II and III were derived from Italy strains that originated in the USA. Based on VP2 protein analysis, CPV 2-I included CPV-2a-like isolates only, as differentiated by the change in residue S297A/N. Almost CPV-2a isolates were classified into CPV 2-III, and a large portion of CPV-2c isolates was classified into CPV 2-II. Two residue substitutions F267Y and Y324I of the VP2 protein were characterized in the isolates of CPV 2-III only.
Conclusions: We provided an updated insight on FPV and CPV-2 genotypes by molecular-based and our findings demonstrate the genetic characterization according to the new genotypes.
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KEYWORD
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Canine parvovirus, feline parvoviruses, classification, genotype
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