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KMID : 0893420210220030033
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Journal of Veterinary Science
2021 Volume.22 No. 3 p.33 ~ p.33
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Dexamethasone reduces infectious bursal disease mortality in chickens
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Shin Seung-Yub
Han Tae-Hee
Kwon Hyuk-Joon
Kim Sun-Joong
Ryu Pan-Dong
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Abstract
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Very virulent infectious bursal disease virus (vvIBDV) causes high mortality in chickens but measures to reduce the mortality have not been explored. Chickens (8?9 weeks) were treated with 3 agents before and during vvIBDV inoculation. Dexamethasone treatment reduced the mortality of infected chickens (40.7% vs. 3.7%; p < 0.001), but treatment with aspirin or vitamin E plus selenium did not affect the mortality. The bursa of Fabricius appeared to have shrunk in both dead and surviving chickens (p < 0.01). The results indicate that dexamethasone can reduce mortality in vvIBDV-infected chickens and may provide therapeutic clues for saving individual birds infected by the virus.
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KEYWORD
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Very virulent infectious bursal disease virus, nitric oxide, bursa of Fabricius, bursa-to-body-weight ratio, aspirin, vitamin E, selenium
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