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KMID : 0893420210220060077
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Journal of Veterinary Science
2021 Volume.22 No. 6 p.77 ~ p.77
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Evaluation of circulating IGF-I and IGFBP-3 as biomarkers for tumors in dogs
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Song Doo-Won
Ro Woong-Bin
Sur Jung-Hyang
Seung Byung-Joon
Kang Hyun-Min
Kim Jong-Won
Park See-Hyoung
Park Hee-Myung
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Abstract
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Background: Serum-based parameters are considered non-invasive biomarkers for cancer detection. In human studies, insulin-like growth factor-I and II (IGF-I and IGF-II) and insulin-like growth factor binding protein-3 (IGFBP-3) are useful as diagnostic or prognostic markers and potential therapeutic targets.
Objectives: This study examined the diagnostic utility of circulating IGF-I, IGF-II, and IGFBP-3 levels in healthy dogs and dogs with tumors.
Methods: The serum concentrations of these biomarkers in 86 dogs with tumors were compared with those in 30 healthy dogs using an enzyme-linked immunosorbent assay (ELISA).
Results: The ELISA results showed no difference between healthy dogs and dogs with tumors in the serum IGF-II concentrations. On the other hand, there was a significant difference in the circulating IGF-I and IGFBP-3 levels between healthy dogs and dogs with tumors. The concentrations of serum IGF-I (median [interquartile range], 103.4 [59.5?175] ng/mL) in dogs with epithelial tumors were higher than those (58.4 ng/mL [43.5?79.9]) in healthy dogs. Thus, the concentrations of serum IGFBP-3 (43.4 ng/mL [33.2?57.2]) in dogs with malignant mesenchymal tumors were lower than those (60.8 ng/mL [47.6?70.5]) in healthy dogs.
Conclusions: The serum IGF-I and IGFBP-3 levels can be used as diagnostic biomarkers in dogs with tumors.
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KEYWORD
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Tumors, biomarkers, insulin-like growth factor, insulin-like growth factor binding proteins, dogs
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