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KMID : 0893420230240010002
Journal of Veterinary Science
2023 Volume.24 No. 1 p.2 ~ p.2
Chronic cold stress-induced myocardial injury: effects on oxidative stress, inflammation and pyroptosis
Hongming Lv

Yvxi He
Jingjing Wu
Li Zhen
Yvwei Zheng
Abstract
Background : Hypothermia is a crucial environmental factor that elevates the risk of cardiovascular disease, but the underlying effect is unclear.

Objectives : This study examined the role of cold stress (CS) in cardiac injury and its underlying mechanisms.

Methods : In this study, a chronic CS-induced myocardial injury model was used; mice were subjected to chronic CS (4¡ÆC) for three hours per day for three weeks.

Results : CS could result in myocardial injury by inducing the levels of heat shock proteins 70 (HSP70), enhancing the generation of creatine phosphokinase-isoenzyme (CKMB) and malondialdehyde (MDA), increasing the contents of tumor necrosis factor-¥á (TNF-¥á), high mobility group box 1 (HMGB1) interleukin1b (IL-1¥â), IL-18, IL-6, and triggering the depletion of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Multiple signaling pathways were activated by cold exposure, including pyroptosis-associated NOD-like receptor 3 (NLRP3)-regulated caspase-1-dependent/Gasdermin D (GSDMD), inflammation-related toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-mediated nuclear factor kappa B (NF-¥êB), and mitogen-activated protein kinase (MAPK), as well as oxidative stress-involved thioredoxin-1/thioredoxin-interacting protein (Txnip) signaling pathways, which play a pivotal role in myocardial injury resulting from hypothermia.

Conclusions : These findings provide new insights into the increased risk of cardiovascular disease at extremely low temperatures.
KEYWORD
Hypothermia, myocardial injury, pyroptosis, inflammation, Signal Transduction
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