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KMID : 0893420230240060077
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Journal of Veterinary Science
2023 Volume.24 No. 6 p.77 ~ p.77
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Simultaneous hypersensitivity reactions to trimethoprim-sulfamethoxazole and amoxicillin-clavulanate in a dog
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Jeong Yun-Ho
Kim Yoon-Hwan
Ahn Jin-Ok
Chung Jin-Young
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Abstract
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Antibiotics are known to be able to cause hypersensitivity reactions through various mechanisms. We present a case of drug-induced immune thrombocytopenia (DITP) and anaphylactic shock occurring simultaneously in a dog after the administration of two classes of antibiotics, namely trimethoprim-sulfamethoxazole (TMP-SMX) and amoxicillin-clavulanate (AMC). The patient recovered completely from DITP on discontinuation of TMP-SMX and the anaphylactic shock caused by AMC was treated with intensive care. DITP is a rare adverse drug reaction (ADR), and anaphylactic shock is a life-threatening ADR. This is the first case report of a dog manifesting two types of hypersensitivity reactions caused by two antibiotics.
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KEYWORD
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Case reports, immune thrombocytopenia, adverse drug reaction, anaphylactic shock, antibiotics
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