KMID : 0895820120220030065
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Journal of Oriental Rehabilitation Medicine 2012 Volume.22 No. 3 p.65 ~ p.78
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Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells
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Jun Kyu-Sang
Kim Il-Hyun Lim Gwang-Mook Song Yuug-Sun
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Abstract
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Objectives :Sodok-eum(xiaodu-y¢§ln, SDU) exhibits potent anti-inflammatory activity with an unknown mechanism. The purpose of this study is to elucidate the molecular mechanisms of SDU on pharmacological and biochemical actions in inflammation.
Methods :We examined the effect of SDU on pro-inflammatory mediators in lipopolysaccharide(UVB)-stimulated HaCaT. The investigation focused on whether SDU inhibited cyclooxygenase-2(COX-2), interleukin-6(IL-6), interleukin-8(IL-8) and mitogen-activated protein kinases(MAPKs) in UVB-stimulated HaCaT cells.
Results :SDU inhibited UVB-induced IL-6, IL-8 productions as well as the expressions of COX-2. Furthermore, SDU suppressed the UVB-induced phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2), c-JUN N-terminal kinase 1/2(JNK 1/2), p38.
Conclusions :These results suggest that SDU has inhibitory effects on UVB-induced IL-6, IL-8 production, as well as the expressions of COX-2 in the HaCaT. The inhibitory effects occur through blockades on the phosphorylation of MAPKs following activation.
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KEYWORD
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Sodok-eum(xiaodu-y¢§ln), UVB, HaCaT, COX-2, IL-6, IL-8, MAPKs
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