KMID : 0900220100170020092
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´ëÇѺñ°úÇÐȸÁö 2010 Volume.17 No. 2 p.92 ~ p.96
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Response of Peripheral Blood Mononuclear Cells toStaphylococcus Aureus Exotoxin in Nasal Polyposis
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Hwang Sang-Hyun
Kim Byung-Guk Kim Soo-Whan Cho Jin-Hee Shin Ji-Hyeon Kang Jun-Myung
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Abstract
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Background and Objectives£ºSuperantigens such as Staphylococcus aureus exotoxin (SE) have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyposis (NP). The aim of this study was to determine the immunologic re¡þsponse of peripheral blood mononuclear cells (PBMCs) to staphylococcal exotoxin B (SEB) in patients with NP.
Methods£ºThe interleukin (IL)-4, IL-5, and interferon-¥ã (IFN-¥ã) responses of PBMCs to nonspecific mitogens such as phylohemagglu¡þtin (PHA) and SEB were examined in 24 NP patients and 16 control subjects. The presence or absence of atopy and asthma was determined to evaluate the correlation of these conditions with the levels of cytokines.
Results£ºPBMCs from the NP patients were more likely to produce IL-4 and IL-5 in response to SEB than those from controls. There was no difference in the mitogen-induced cytokine responses between NP patients and controls. SEB-induced IL-5 and IL-4 levels were higher in patients with NP with asthma than in patients with NP without asthma.
Conclusion£ºPatients with NP show an exaggerated Th2 cytokine response of PBMCs to SEB.
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KEYWORD
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Nasal polyposis, Staphylococcus aureus exotoxin, Peripheral blood mononuclear cell
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