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KMID : 0900920010250040349
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Korean journal of Animal Reproduction
2001 Volume.25 No. 4 p.349 ~ p.357
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Effects of Caffeine and Dietary Fat on Mouse Mammary Development
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Lee Seung-Yop
Yuh In-Suh
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Abstract
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This study was conducted to examine the effect of caffeine and three dietary levels of fat, i.e., 0%, 5% and 20% on mammary gland development. Mice were assigned to three groups (dietary levels 0%, 5%, 20% fat), and treated caffeine of half within the each group. Caffeine-treated mice with 0% or 20% fat levels significantly increased 4^{th} mammary gland development in comparison with that of no caffeine -treated mice (P＜0.05). Caffeine-treated mice significantly increased DNA contents of 4^{th} mammary gland in comparison with that of no caffeine-treated mice (P＜0.05), and DNA contents of mammary gland increased as fat levels increased within caffeine-treated or no caffeine-treated group. nteraction effect was shown between caffeine and 20% fat diet, ［(20% fat+caffeine) - (20% fat + no caffeine) vs (0% fat + caffeine) - (0% fat + no caffeine)］(P＜0.01). Conclusively, caffeine significantly increased mouse mammary gland development possibly by inhibiting phosphodiesterase activity, and dietary fat supplements increased mammary gland development as the fat content of the diet increased from 0 to 20%. The stimulatory effect of caffeine in mammary development interacted with high level of fat diet.
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KEYWORD
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Caffeine, Dietary fat, Mammary development, Mammary tissue
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