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KMID : 0911920000010010012
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Korean Journal of Cardiovascular Diseases
2000 Volume.1 No. 1 p.12 ~ p.23
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Remodeling and Restenosis
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Mintz, Gary S.
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Abstract
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Except in diabetic patients, late responses to non-stent coronary interventions are determined less by intimal hyperplasia tan by the direction and magnitude of arterial remodeling. Negative arterial remodeling is a late event, is often preceded by an early (non-sustained) positive remodeling, and is distinct from passive elastic recoil. Diabetics have an exaggerated intimal hyperplastic response. Plaque burden may play an important role in the restenosis process by amplifying the negative remodeling. Stents reduce restenosis by opposing the late negative remodeling to offset a stent related increase in neointimal hyperplasia. Both probucol and radiation appear to reduce late lumen loss after ballon angioplasty by promoting positive remodeling. (Korean J Cardiovasc Dis 2000;1:12-23)
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KEYWORD
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