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KMID : 0911920010020010054
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Korean Journal of Cardiovascular Diseases
2001 Volume.2 No. 1 p.54 ~ p.62
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Lipoprotein(a) Level in Atherosclerotic Vascular Disease
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Park, Hoon Gi
Seo, Hong Seog/Oh, Dong Joo/Lee, Eun Mi/Ahn, Jung Cheon/Park, Chang Gyu/Park, Hee Nam
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Abstract
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Background - Many studies have suggested an association of atherosclerotic vascular disease with a high lipoprotein (a) [LP(a)] serum level. Its association is derived from the structure-based functional characteristics of Lp(a) and the existence of Lp(a) in atherosclerotic plaque. However, the exact biological and physiological role of Lp(a) is unknown. The serum [LP(a)] level varies widely between individuals, but remains relatively constant in an each individual and is mainly determined by the apolipoprotein (a) [apo(a)] size and its polymorphism. The aim of this study was to determine whether the Lp(a) level at the same apo(a) phenotype is elevated in atherosclerotic vascular diseases.
Methods and Results. - The average Lp(a) serum concentation in the ptients group (33.6±30.2㎎/dl) was slightly higher than in the control group (27.8±27.2㎎/dl). The size of apo(a) was analyzed by polyacrylamide gel electrophoresis and immunoblotting, and the Lp(a) level was compared at each apo (a) size between atherosclerotic vasular group and control group.
Ninety-four(46.8%) and 30(15.0%) subjects out of 201 patients with athersclerotic vascular disease had the S4 and S3 phenotype of apo(a) respectively. One hundred twenty-four (44.3%) and 58(20.7%0 subject out of 281 people without athersclerotic vascular disease had the S4 and S3 phenotype of apo(a), respectively. The seunm Lp(a) levels of the S2, S3 and S4 phenotype of the apo(a) patients were high than those of the controls (S2:49.7±22.8㎎/dl vs 40.3±16.2㎎/dl, p=0.05; S3:33.6±30.2㎎/dl vs 33.8±14.7㎎/dl, p<0.05 ; S4:16.3±11.2㎎/dl vs 13.4±10.1㎎/dl, p<0.05), respectively. The prevalence of disease in each apo(a) phenotype was not different.
Conclusions.- This result shows that patients with atherosclerosis had higher Lp9a) levels with the same genetic tratis of apo(a) polymorphism. We suggest that the higher than average Lp protein(a) level in each apo(a) phenotype may be related to result of atherosclerosis especially in the high risk group.(Korean J Cardiovasc Dis 2001;2:54-62)
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