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KMID : 0921620150450040354
Journal of Bacteriology and Virology
2015 Volume.45 No. 4 p.354 ~ p.363
Eosinophils are Required for Immune Responses Induced by Oral Immunization
Jung Yun-Jae

Abstract
Eosinophils are multifunctional leukocytes that reside in several tissues, most abundantly in the small intestinal lamina propria under the steady state. To date, the phenotypic and functional characteristics of small intestinal eosinophils have remained poorly understood. In this study, we found that proliferation of ovalbumin (OVA)-specific CD4+ T cells isolated from the mesenteric lymph nodes of eosinophil-deficient ¥ÄdblGATA mice were decreased relative to wild-type mice after oral immunization with OVA and cholera toxin (CT), the typical mucosal adjuvant that induces CD4+ T cell-dependent responses. ¥ÄdblGATA mice showed reduced mucosal secretion of OVA-specific IgA and IgG1 while maintaining a systemic level of anti-OVA IgG1 upon oral immunization with OVA and CT. These findings suggest that eosinophils might have a role in the modulation of T cell-mediated immune responses including mucosal antibody responses in the gastrointestinal tract following oral immunization.
KEYWORD
Eosinophils, Small intestine, Mucosal immunity, Oral immunization, Antibody responses
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