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KMID : 0985420240460010038
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Laboratory Medicine and Quality Assurance
2024 Volume.46 No. 1 p.38 ~ p.42
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Reference Intervals for Research Parameters of Reticulocyte Hemoglobin and Platelet Clumps in Healthy Korean Adults
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Kim Mi-Young
Hong Sang-Kyoon
Kim Nan-Young
Jeon Ki-Bum
Lee Ji-Won
Kim Han-Sung
Kang Hee-Jung
Lee Young-Kyung
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Abstract
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Background: Automated hematology analyzers report various research parameters. Certain parameters may have clinical implications, whereas others are used to set flags in automated hematology analyzers. In this study, we established sex-specific reference intervals for one reticulocyte parameter and two platelet clump parameters in Korean adults and examined the necessity of separate reference intervals for each sex.
Methods: A total of 264 healthy adults (157 men and 107 women) aged between 18 and 65 years who underwent regular health check-ups were enrolled. Complete blood cell count was measured using Advia2120i (Siemens, Germany) within 4 hours of phlebotomy. Reference intervals were established according to the Clinical and Laboratory Standards Institute EP28-A3 guideline, and the necessity of separate sex-specific reference intervals was examined according to the method outlined by Harris and Boyd.
Results: The reference intervals for each parameter were as follows: reticulocyte hemoglobin (g/L), 132.8?172.0 (men), 96.7?162.8 (women); the number of platelet clumps (# platelet clumps), 10.8?61.0 (men), －22.5?64.4 (women); and %platelet clumps, 0.20?1.49 (men), －0.57?1.53 (women). Reticulocyte hemoglobin showed a significant difference between men and women, whereas # platelet clumps and %platelet clumps did not; however, all three parameters needed separate sex-specific reference intervals.
Conclusions: We established sex-specific reference intervals for a reticulocyte parameter and platelet clumps parameters in Korean adults for the first time. The results could provide helpful information in clinical decision-making and instrument setting.
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KEYWORD
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Reference interval, Reticulocyte hemoglobin, Platelet clumps, Korean
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