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KMID : 1001920040350020136
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Journal of Korean Neurosurgical Society
2004 Volume.35 No. 2 p.136 ~ p.141
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The Role of Adjunctive Therapy of Optic Pathway Glioma in Children
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Jang Jong-Ho
Ra Young-Shin
Kim Jeong-Hoon
Lee Jung-Kyo
Khang Shin-Kwang
Ghim Thad
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Abstract
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Objective : This study is performed in order to compare the outcomes of surgical management and to define the role of adjunctive therapy in the management of optic pathway glioma in children.
Methods : Sixteen children with optic pathway glioma had been managed in various treatment methods during the last 8 years. The patients aged from 5 months to 14 years. The patients presented with progressive visual loss, increased ICP symptoms, endocrine dysfunction, seizure, and motor weakness. Optic pathway glioma associated with neurofibromatosis was excluded. Tumor involved chiasmatico-hypothalamus(12 patients), optic chiasm(3), and optic nerve(1). The extent of surgical resection were radical(3 patients), subtotal(] 2), and partial(1).
Results :Three patients treated with radical resection showed no evidence of tumor recurrence. Among 12 patients treated with subtotal resection and without adjunctive therapy, 6 patients(50%) developed recurrence in the postoperative period of average 20.5 months. Those patients with recurrence were managed by reoperation(3 patients), irradiation ti-erapy(2), and chemotherapy(1). However three patients with residual tumors after subtotal(2), or partial(1) resection were treated with adjunctive chemotherapy in the postoperative period showed no evidence of recurrence.
Conclusion : Although radical resection of optic pathway glioma might offer long-term control of tumor, adjunctive chemotherapy could be effective to prevent tumor recurrence in children with subtotally or partially resected optic pathway glioma. More experience is necessary to determine the optimal method of treatment of optic pathway gliomas in children.
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KEYWORD
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Optic pathway glioma, Surgery, Radiotherapy, Chemotherapy, Outcome, Children
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