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KMID : 1001920110490060334
Journal of Korean Neurosurgical Society
2011 Volume.49 No. 6 p.334 ~ p.338
The Clinical Features of Spinal Leptomeningeal Dissemination from Malignant Gliomas
Bae Jung-Sik

Yang Seung-Ho
Yoon Woan-Soo
Kang Seok-Gu
Hong Yong-Kil
Jeun Sin-Soo
Abstract
Objective : The incidence of leptomeningeal dissemination from malignant glioma is rare, so the clinical features of this are not well documented yet. We attempted to determine the clinical features of leptomeningeal dissemination from malignant gliomas.

Methods : We retrospectively analyzed 11 cases of leptomeningeal dissemination of malignant glioma, who were treated at our institution between 2006 and 2009. We investigated the clinical features of these patients by considering the following factors : tumor locations, the events of ventricular opening during surgery and the cerebrospinal fluid (CSF) profiles, including the cytology.

Results : The group was composed of 9 males and 2 females. The histological diagnosis of their initial intracranial tumors were 4 primary glioblastoma, 3 anaplastic astrocytoma, 1 anaplastic oligoastrocytoma, 2 ganglioglioma and 1 pleomorphic xanthoastrocyotma with anaplastic features. The mean age of the patients at the time of the initial presentation was 42.8¡¾10.3 years. The mean time between surgery and the diagnosis of spinal dissemination was 12.3¡¾7.9 (3-28) months. The mean overall survival after dissemination was 2.7¡¾1.3 months. All our patients revealed a history of surgical opening of the ventricles. Elevated protein in the CSF was reported for eight patients who had their CSF profiles checked.

Conclusion : We propose that in the malignant gliomas, the surgical opening of ventricles can cause the spinal leptomeningeal dissemination and the elevated protein content of CSF may be a candidate marker of leptomeningeal dissemination.
KEYWORD
Seeding, Malignant glioma, Spinal dissemination
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