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KMID : 1007520140230041261
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Food Science and Biotechnology
2014 Volume.23 No. 4 p.1261 ~ p.1266
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Antidiabetogenic and Antioxidative Effects of Octaphlorethol A Isolated from the Brown Algae Ishige foliacea in Streptozotocininduced Diabetic Mice
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Lee Seung-Hong
Kang Na-Lae
Kim Eun-A
Heo Soo-Jin
Moon Sang-Ho
Jeon Byong-Tae
Jeon You-Jin
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Abstract
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The antidiabetogenic and antioxidative effects of octaphlorethol A (OPA) isolated from the brown algae Ishige foliacea in streptozotocin (STZ)-induced diabetic mice were analyzed. STZ-induced diabetic mice showed a significant (p<0.05) increase in blood glucose and lipid peroxidation levels and a significant (p<0.05) decrease in the plasma insulin level and body weight, compared with controls. Diabetic mice also showed a significant (p<0.05) decrease in the activities of the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-px), compared with controls. Oral treatment with OPA (5 and 10 mg/kg) showed protective effects against all the biochemical parameters studied. OPA-treated mice exhibited suppression of apoptosis, and treatment with OPA was associated with an increase in antiapoptotic BclxL expression and a reduction in pro-apoptotic Bax and cleaved caspase-3 expressions. OPA has antidiabetogenic and antioxidative effects, and potential for use in therapies as both a natural functional food and a pharmaceutical agent.
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KEYWORD
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octaphlorethol A, antidiabetogenic, antioxidative, streptozotocin, diabetic mice
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