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KMID : 1007520180270041165
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Food Science and Biotechnology
2018 Volume.27 No. 4 p.1165 ~ p.1173
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SMYD3-associated pathway is involved in the anti-tumor effects of sulforaphane on gastric carcinoma cells
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Dong Qing-Qing
Wang Qiu-Tong
Wang Lei
Jiang Ya-Xin
Liu Mei-Ling
Hu Hai-Jie
Liu Yong
Zhou Hao
He Hong-Peng
Zhang Tong-Cun
Luo Xue-Gang
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Abstract
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Sulforaphane (SFN), a natural compound derived from cruciferous vegetables, has been proved to possess potent anti-cancer activity. SMYD3 is a histone methyltransferase which is closely related to the proliferation and migration of cancer cells. This study showed that SFN could dose-dependently induce cell cycle arrest, stimulate apoptosis, and inhibit proliferation and migration of gastric carcinoma cells. Accompanied with these anti-cancer effects, SMYD3 and its downstream genes, myosin regulatory light chain 9, and cysteine-rich angiogenic inducer 61, was downregulated by SFN. Furthermore, overexpression of SMYD3 via transfection could abolish the effects of SFN, suggesting that SMYD3 might be an important mediator of SFN. To the best of our knowledge, this is the first report describing the role of SMYD3 in the anti-cancer of SFN. These findings might throw light on the development of novel anti-cancer drugs and functional food using SFN-rich cruciferous vegetables.
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KEYWORD
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Sulforaphane, SET and MYND domain containing 3, Cell cycle, Apoptosis, Migration
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