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KMID : 1007520190280010253
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Food Science and Biotechnology
2019 Volume.28 No. 1 p.253 ~ p.260
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Aqueous extract of Lespedeza cuneata improves male menopause by increase of nitric oxide and dihydrotestosterone
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Rhee Yun-Hee
Yoo Sang-Woo
Lee Seong
Chung Phil-Sang
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Abstract
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This study aimed to evaluate the effect of aqueous extract of Lespedeza cuneata (ALC) on men menopause induced erectile dysfunction (ED) and testosterone deficiency syndrome (TDS) in vitro and in vivo. Nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) have been fundamental factors of ED, and free testosterone such as dihydrotestosterone (DHT) has a crucial role in mitigation of TDS. ALC increased the production of NO in a dose-dependent manner in vitro and in vivo. The level of neuronal nitric oxide synthase and cGMP was increased in the ALC group. The level of DHT and 17-beta hydroxysteroid dehydrogenases (17β-HSD) was also increased in the ALC group. There was no significant change of hepatotoxicity, renal toxicity, lipid metabolism, and glucose. These results suggest that ALC enhanced NO, cGMP and free testosterone which could be developed as a health supplement for improving male menopause.
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KEYWORD
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Aqueous extract of Lespedeza cuneata (ALC), NO, cGMP, Free testosterone, Male menopause
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