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KMID : 1007520190280051577
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Food Science and Biotechnology
2019 Volume.28 No. 5 p.1577 ~ p.1582
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Effect of Chrysanthemum indicum Linne extract on melanogenesis through regulation of TGF-β/JNK signaling pathway
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Hwang Yong-Il
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Abstract
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Although several physiological effects of Chrysanthemum indicum Linne (CL) have been researched, the specific effect and molecular mechanism of CL as a functional food material for skin health remain still unknown. Here, it was observed that the α-MSH and IBMX-initiated B16F10 melanogenesis was suppressed by the CL water extract (CLE) treatment. The CLE treatment also increased the mRNA expression levels of pro-collagen1α2, collagen1α2, and fibronectin via exerting the TGF-β/JNK signaling pathway. Together, the beneficial role of CLE in skin health was demonstrated through the downregulation of melanogenesis and enhancement of skin fibril-related genes. It was also revealed that the function of CLE is mediated with the activation of the TGF-β/JNK signaling pathway. These results may provide evidences for the development of functional foods using CLE for maintaining healthy skin.
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KEYWORD
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Chrysanthemum indicum Linne, Skin, TGF-β, Melanin, Skin fibril
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