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KMID : 1011920200210010017
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International Journal of Arrhythmia
2020 Volume.21 No. 1 p.17 ~ p.17
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In a case of female-to-male sex reassignment, testosterone therapy switches on an underlying Brugada
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Vivona Patrizia
Dagradi Federica
Ciulla Michele M.
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Abstract
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Background: The Brugada syndrome, diagnosed by a typical electrocardiographic pattern, is a genetic condition characterised by an increased risk of potentially lethal ventricular arrhythmias and sudden cardiac death. Even if its pathophysiological mechanism is unknown, its prevalence in male suggested a possible hormonal involvement.
Case presentation: In this case involving a woman who underwent a female-to-male sex reassignment, we documented that testosterone administration was able to switch on and, when stopped, to switch off a latent pattern of Brugada.
Conclusions: Our observation strongly supports a possible involvement of testosterone in the ECG manifestation of Brugada syndrome even if the general low prevalence of the Brugada syndrome does not support to screen every female-to-male sex reassignment.
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KEYWORD
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Brugada syndrome, Testosterone, Sex change
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