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KMID : 1012020130020020063
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Physical Therapy Rehabilitation Science
2013 Volume.2 No. 2 p.63 ~ p.69
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The use of laser Doppler blood flow to assess the effect of acute administration of vitamin D on micro vascular endothelial function in people with diabetes
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Jerrold Petrofsky
Faris Alshammari
Iman Akef Khowailed
Riya Lodha
Pooja Deshpande
Praveen Rajaram
Mahendra Gaikwad
Vidhi Vadera
Alshammari Faris
Khowailed Iman Akef
Lodha Riya
Deshpande Pooja
Gaikwad Mahendra
Vadera Vidhi
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Abstract
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Objective: To assess the effect of vitamin D administration on the skin blood flow response to occlusion and heat.
Design: Cross-sectional study.
Methods: Twenty age matched subjects; 10 who had diabetes and 10 who were controls were administered 4,000 IU of vitamin D3 for 3 weeks at breakfast. The function of the endothelial cells was evaluated in 2 ways; first, the response to 4 minutes of vascular occlusion of the skin was measured with a laser Doppler flow meter. Second, the skin blood flow response to local heat at 42 degrees C for 6 minutes was examined.
Results: The results of the experiments showed that the blood flow response to heat was reduced after 3 weeks administration of vitamin D in the subjects with diabetes and in the control subjects (p<0.05). The response to occlusion was not significantly different within each group before and after vitamin D administration, but the group with diabetes had a significantly lower blood flow response to occlusion than did the controls (p<0.05).
Conclusions: Acute doses of vitamin D may impair nitric oxide production and reduce blood flow to tissue during stressors in people with diabetes.
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KEYWORD
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Diabetes, Endothelial cells, Inflammation, Vitamin D
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