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KMID : 1012020170060040170
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Physical Therapy Rehabilitation Science
2017 Volume.6 No. 4 p.170 ~ p.175
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Anti-inflammatory effects of low-level laser in burn wound models in rats
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Kim Eun-Jeong
Kim Se-Hun
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Abstract
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Objective: The anti-inflammatory effects of low-level laser in burn wound model in rats were investigated.
Design: Randomized controlled trial.
Methods: The rats were assigned to three experimental groups. Group I received second-degree burn wounds; Group II received dressing film and low-level laser (1.2 J/cm2) treatment after a burn wound; Group III received dressing film and low-level laser (2.3 J/cm2) treatment after a burn wound. After inducing a deep second-degree burn wound, the wound was observed every day and the burn area diameter and retraction quantification at 1, 7, and 14 days were evaluated. Low-level laser was investigated on hematological parameters after 14 days. Effects of low-level laser on the inflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]) concentrations in the serum were evaluated using immunosorbent assay kits.
Results: Group III showed a significant difference in wound size on days 7 and 14 compared to Group I (p<0.05). Group II showed a significant difference in wound size on day 14 compared to Group I (p<0.05). For wound contraction percentage, both laser therapy treatment groups showed a significant difference compared with Group I (p<0.05). There was also a significant difference in wound contraction percentage in Group III compared to Group II (p<0.05). Compared with the model control group, decreased TNF-α and IL-6 levels in the serum was observed at 14 days after burn wound induction.
Conclusions: The results of this study suggest that low-level laser therapy can assist in burn wound healing, which might be associated with decreased concentrations of TNF-α and IL-6 related proinflammatory cytokines.
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KEYWORD
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Inflammation, Low-level lasers, Wounds
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