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KMID : 1012020210100020175
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Physical Therapy Rehabilitation Science
2021 Volume.10 No. 2 p.175 ~ p.184
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Effects of Red Ginseng on Exercise Capacity and Peripheral Fatigue in Mice
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Kim Dae-Hyun
Lee Byoung-Gwan
Kim Hee-Jin
Kim Mi-Kyung
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Abstract
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Objective: Fatigue can decrease both quality of life and work efficiency. Ginseng is one of the most popular herbal treatments for improving personal health, with applications in treating fatigue. However, the exact mechanisms of anti-fatigue effects are still unclear. Thus, we investigated the effect of red ginseng powder (RGP) on exercise capacity and peripheral fatigue using both behavioral and molecular experiments in mice.
Design: Four-groups behavioral and molecular experiment.
Methods: Male 6-weeks-old ICR mice were treated with distilled water, 100, and 200 mg/kg RGP for 5 days via oral administration. The exercise capacity of each animal group was measured by locomotor activity, rota-rod, hanging wire, and cold swimming tests. Additionally, after performing the treadmill to induce fatigue, lactate expression and molecular experiments were investigated using mice gastrocnemius.
Results: Mice treated with RGP exhibited increased exercise capacity in the behavioral tests. Additionally, RGP induced a dose-dependent decrease in lactate levels after high-intensity exercise, and Monocarboxylate transporter (MCT) 4 expression increased in groups treated with RGP. However, there was no significant change in MCT1.
Conclusions: These results suggest that RGP exerts several anti-fatigue properties by lower lactate and improved exercise capacity. Increased MCT4 expression may also affect lactate transport. Thus, this study suggests that the anti-fatigue properties of RGP might be associated with MCT4 activity.
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KEYWORD
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Red ginseng, Fatigue, Monocarboxylate transporter, Lactate, Exercise capacity
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