|
KMID : 1012320050080030153
|
|
Nutritional Sciences
2005 Volume.8 No. 3 p.153 ~ p.158
|
|
|
Inhibitory Effects of Licochalcone A and Isoliquiritigenin on Monocyte Adhesion to TNF--activated Endothelium
|
|
Kwon Hyang-Mi
Lim Soon-Sung
Choi Yean-Jung
Jeong Yu-Jin
Kang Sang-Wook
Bae Ji-Young
Kang Young-Hee
|
|
|
Abstract
|
|
|
|
Numerous natural herbal compounds have been reported to inhibit adhesion and migration of leukocytes to the site of inflammation Licorice extracts, which have been widely used in traditional Chinese medicinal preparation, possess various pharmacological effects. Isoliquiritigenin, a biogenetic precursor of flavonoids with various pharmacological effects, is a natural pigment present in licorice. We attempted to explore whether licorice extracts and isoliquiritigenin mitigate monocyte adhesion to tumor necrosis factor-α(TNF-α)-activated human umbilical vein endothelial cells (HUVEC). In addition, it was tested whether the inhibition of monocyte adhesion to the activated HUVEC accompanied a reduction in vascular cell adhesion molecule-l expression(VCAM-l). Dry-roasted licorice extracts in methylene chloride but not in ethanol markedly interfered with THP-l monocyte adhesion to INF-α-activated endothelial cells. licochalcone A compound isolated from licorice extract in methylene chloride appeared to modestly inhibit the interaction of THP-l monocytes and activated endothelium. In addition, isoliquiritigenin abolished the monocyte adhesion with attenuating VCAM-l protein expression on HUVEC induced by INF-α. These results demonstrated that non-polar components from dry-roasted licorice extracts containing licochalcone A as well as isoliquiritigenin were active in blocking monocyte adhesion to cytokine-activated endothelimn, which appeared to be mediated most likely through the inhibition of VCAM-l expression on HUVEC. Therefore, licorice may hamper initial inflammatory events on the vascular endothelium involving induction of endothelial cell adhesion molecules.
|
|
|
KEYWORD
|
|
|
Glycyrrhizae radix extract, Isoliquiritigenin, Licochalcone A, Vascular cell adhesion molecule-1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|