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KMID : 1012320050080030196
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Nutritional Sciences
2005 Volume.8 No. 3 p.196 ~ p.199
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Study of Thyroid-Related Hormones During Second Trimester of Pregnancy
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Laeeq Faiqa
Nagra Saeed Ahmad
Elahi Shan
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Abstract
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A study during second trimester of pregnancy was conducted among 100 women from a population with mild to moderate deficient iodine intake (median 7 ㎍/L)to monitor the changes in serum free thyroxin (FT4), triiodothyionine (T3) and thyrtropin (TSH). Thyroid related hormones were assessed using radioimmunoassay (RIA) and immunoradiometricassay (IRMA). As compared with non pregnant women, mean FT4 levels decreased, T3 levels increased and TSH levels were slightly depressed in pregnant women. Mean FT4 concentration reached its highest level in the 4th month and linearly decreased until the 6th month. Mean T3 level remained almost constant during 2nd trimester of pregnancy. Mean TSH level remained unaltered during the 4th and 5th months and was slightly lower than that for the control group. However, these differences were statistically insignificant At the end of the second trimester, hypothyroxinemia and T3 levels greater than the upper limit of the laboratory reference range were found in34% and 38% of women, respectively. These changes in thyroid hormones reflect typical adaptations of the thyroid gland during pregnancy to the limited availability of iodine.
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KEYWORD
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Iodine deficiency, Pregnancy, Pakistan
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