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KMID : 1012320050080040212
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Nutritional Sciences
2005 Volume.8 No. 4 p.212 ~ p.218
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Evaluation of the Efficacy of Kochiae fructus Extract in the Alleviation of Carbon Tetrachloride-induced Hepatotoxicity in Rats
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Kim Na-Young
Lee Jeong-Sook
Kim Seog-Ji
Park Myoung-Ju
Kim Seok-Hwan
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Abstract
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Hepatoprotective effects of the extract of Kochiae fructus (KF), a traditional oriental medicinal plant, were evaluated against carbon tetrachloride(CCl4)-induced liver damage in rats. Male Sprague-Dawley rats were divided into control, CCl4, CCl4plus methanol extract of KF (KFM- CCl4), and CCl4plus butanol extract of KF (KFB- CCl4) groups. KFM and KFB were orally administered once a day (200 mg/kg body weight) for 14 days. A mixture of 0.2 mL/100 g body weight of CCl4in olive oil was injected at 30 minutes after the final administration of KFM and KFB. The KFB pretreatment resulted in a significant decrease in the serum transaminase and lactic dehydrogenase levels in the CCl4-treated rats. The CCl4 treatment significantly lowered the activities of glutathione, glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px). However, pretreatment with KFM and KFB resulted in a significant increase in the glutathione, GR and GST levels. KFB increased the activities of SOD, catalase and GSH-Px, but KFM did not alter them. Pretreatment with KFM and KFB resulted in a significant decrease in the production of aminopyrine N-demethylase in the CCl4 -treated rats. KF extract would appear to contribute to alleviate the adveISe effect of CCl4 treatment by enhancing the hepatic antioxidant defense system.
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KEYWORD
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Kochiae fructus, Carbon tetrachloride, Hepatotoxicity
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