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KMID : 1012320050080040226
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Nutritional Sciences
2005 Volume.8 No. 4 p.226 ~ p.230
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The Inhibitory Activity of Polygonum Multiflorum Thunberg and its Effect on Postprandial Hyperglycemia in Streptozotocin-induced Diabetic Rats
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Kang Min-Jung
Kim Jung-In
Joo Hee-Jeong
Seo Tae-Jin
Kim Hyun-Ah
Han Jung-Hee
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Abstract
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To keep blood glucose levels as close to normal as possible is the major goal of diabetes mellitus treatment α-Glucosidase is the enzyme that digests die1my carbohydrate and inhibition of this enzyme may suppress postprandial hyperglycemia. The methanol extract of Polygonum multiflorum Thunberg was tested for inhibitoty activity against α-glucosidase in vitro and in vivo. Polygonum multiflorum Thunberg extract inhibited yeast α-glucosidase activity in a concentration-dependent manner. Polygonum multiflorum Thunberg showed an IC50 value of 0.48 mg/mL. The ability of Polygonum multiflorum Thunberg extract to lower postprandial glucose was studied in streptozotocin-induced diabetic rats. A starch solution (1 g/kg) with and without the methanol extract of Polygonum multiflorum Thunberg extract (500 mg/kg) was administered to diabetic rats by gastric intubation after an overnight fast A single oral dose of Polygonum multiflorum Thunberg extract significantly inhibited increases in blood glucose levels at 60 and 90 min (p<0.05) and significantly decreased incremental response areas under the glycemic response curve (p<0.05). These results suggest that Polygonum multiflorum Thunberg may have an antihyperglycemic effect by inhibiting α-glucosidase activity in the animal model of diabetes mellitus.
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KEYWORD
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Polygonum multiflorum Thunberg, Antihyperglycemic effect, Diabetes mellitus
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