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KMID : 1012320060090030167
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Nutritional Sciences
2006 Volume.9 No. 3 p.167 ~ p.172
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Effect of Platycodon Grandiflorum Aqueous Extract on Lipid Levels in Rats
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Kim Jeong-Seon
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Abstract
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This study investigated the effects of Platycodon grandiflorum aqueous extract on lipid concentration of serum and liver in rats fed high cholesterol diet Male Sprague-Dawley rats were assigned to three groups (control, low dose of extract, high dose of extract) for four weeks. The serum total cholesterol concentration was significantly lower in the low and high doses of extract groups than in the control group. There was a significant decrease in the free cholesterol, cholesterol ester, LDL-cholesterol, and triglycerides concentrations in serum, and the total cholesterol and the triglycerides contentin liver in the low and high doses of extract groups compared to the control group. When the serum phospholipid concentration was compared among the groups, it was significantly lower in high dose of extract group than in control and low dose of extract group. It can be postulated that Platycodon grandiflorum aqueous extract may possess substantial hypolipidemic properties in rats.
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KEYWORD
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Platycodon grandiflorum, Lipids, Serum, Liver, Rats
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