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KMID : 1012320060090040259
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Nutritional Sciences
2006 Volume.9 No. 4 p.259 ~ p.266
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Quercetin Supplement is Beneficial for Altering Lipid Metabolism and Antioxidant Enzyme Activities in the Middle of Ethanol Feeding in Rats
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Seo Hyun-Ju
Kim Soon-Ja
Do Gyeong-Min
Choi Myung-Sook
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Abstract
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The current study examined the effect of quercetin supplements on the lipid-lowering and antioxidant metabolism in ethanol-fed rats. The control group(E8) received ethanol only diet for 8 wks, whereas the other group (E8O4) received a diet including quercetin supplementation(0.05% wt/wt) for 4 wks while on the ethanol diet for 8wks. The hepatic alcohol dehydrogenase activity was significantly higher in the E8O4 group than in the E8 group. Supplementation with quercetin significantly elevated the HDL- cholesterol concentration, the HDL-C/total-C ratio, and lowered the atherogenic index(AI) compared to the E8 group. The hepatic triglyceride and cholesterol contents were significantly lowered by the quercetin supplement compared to those of the control group. The hepatic HMG-CoA reductase and ACAT activities of the E8O4 group were significantly lower than those of the E8 group. The overall potential for antioxidant defense was significantly enhanced by the quercetin supplement, as indicated by a decrease in plasma and hepatic TBARS levels. The hepatic GSH-Px and G6PD activities were significantly higher in the E8O4 group compared to the E8 group. The current results suggest that dietary quercetin leads to the inhibition of HMG-CoA reductase and ACAT, which in turn lowers cholesterol levels and normalizes antioxidant enzyme activities.
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KEYWORD
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Quercetin, Ethanol-diet, HMG-CoA reductase, ACAT, Antioxidant enzyme activity
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