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KMID : 1012320060090040295
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Nutritional Sciences
2006 Volume.9 No. 4 p.295 ~ p.300
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Clinical Study on the Iron Absorption from Heme-Iron Polypeptide and Nonheme-Iron
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Nam Tae-Sik
Shim Ji-Yeon
Kim Byung-Ju
Rah So-Young
Park Kwang-Hyun
Kim Seon-Young
Mun Eun-Gyeng
Jeong Young-Ju
Han Myung-Kwan
Cha Youn-Soo
Chae Soo-Wan
Im Mie-Jae
Kim Uh-Hyun
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Abstract
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Iron bound to heme appears to be more bioavailable than iron salts. A clinical study was performed to investigate the absorption efficiency of heme-iron and iron-salt products available. Heme-iron and nonheme-iron supplements have become available in Korea. We performed iron absorption studies to compare the absorption of heme-iron polypeptide (HIP) products made from digested hemoglobin, produced in Korea (HIPk) and imported from Japan (HIj), with that of iron salts. In the study, 80 subjects were divided into 5 groups (n=56): placebo group; 12 mg glucose, HIPk group; 12 mg iron as HIPk, HIj group; 12 mg iron as HIj, iron-salt group 1; 12 mg of iron as ferrous aminoacetate, and iron-salt group 2; 100 mg iron as ferrous aminoacetate. Changes in serum iron levels were measured at 3 and 5 hours post ingestion. Absorption of iron in HIPk was higher compared to HIj, iron-salt or placebo. There was a significant inverse correlation between low serum iron levels $(<80{\mu}g/dl)$ and iron absorption from HIPk. These results demonstrated that HIPk was more bioavailable, even taken with a meal, and would have potential advantages over iron salt or HIj as an iron supplement. Our results indicate that heme-iron absorption is regulated by iron status through a heme receptor, whereas iron-salt absorption is unregulated.
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KEYWORD
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Heme-iron, Iron salt, Iron absorption, Iron supplement, Iron deficiency
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