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KMID : 1023519920150020166
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Korean Journal of Veterinary Service
1992 Volume.15 No. 2 p.166 ~ p.173
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Effect of Deoxynivalenol on Immunoglobulin in the Mouse
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Lee Kuk-Cheon
Lee Ju-Hong
Son Seong-Gi
Joo Young-Kuk
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Abstract
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Mice were fed semi-purified diets containing 0, 2, 10 and 25 ppm(mg/kg) deoxynivalenol over 8 weeks and were assessed for effects on bodyweight gain, serum immunolglobulin levels and surface immunoglobulin bearing lymphocyte ratio. 1. The rate of body-weight gain was significantly reduced (p＜0.05) at the 10 and 25 ppm of DON, whereas the mice ingesting the diet containing 2 ppm DON was not. 2. IgA in serum immunolglobulin was significantly increased (P＜0.05) at the 10 and 25 ppm of DON, but IgG, IgM were decreased, whereas exposure to 2 ppm DON was not change. 3. Concentration of IgA from Peyer’s patch of mice fed DON exhibited increased at 10, 25 ppm. 4. Lymphocytes surface marker studies revealed that IgA, IgG and IgM were 2.2%, 0.4% and 1.5％ respectively. These results suggest that dietary exposure to DON alters regulation of IgA production
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KEYWORD
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Deoxynivalenol(DON), body-weight, immunoglobulin
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