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KMID : 1023520020250010097
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Korean Journal of Veterinary Service
2002 Volume.25 No. 1 p.97 ~ p.103
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Evolution of avian infectious bronchitis virus: Genetic drift and recombination
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Lee Chang-Won
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Abstract
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Infectious bronchitis(IB) is a viral disease in which continued evolution of the virus is of paramount importance for annual endemics and epidemics in chickens. Since the isolation of IB viruses(IBVs) in the 1930s, over 50 serotypes or variants have been reported worldwide. Continuing evolution is most prominent in the suface glycoproteins of IBV but also occurs in other parts of the genome. This genetic variability results from accumulation of molecular changes that can occur by a number of different mechanisms including genetic drift (point mutations) and genetic shift(RNA recombination). GA98 is a new serotype of IBV identified recently in the United States. In this paper, the evolutionary trend of IBV will be discussed using GA98 serotype as a model.
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KEYWORD
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Infectious bronchitis virus, Evolution, Genetic drift, Recombination
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