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KMID : 1023520020250030221
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Korean Journal of Veterinary Service
2002 Volume.25 No. 3 p.221 ~ p.227
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Study on analytical method of residual macrolide antibiotics in livestock products by LC/MS
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Hwang Lae-Hwong
Yun En-Sun
Kim Yoen-Joo
Kim Dong-Eon
Yang Yun-Mo
Lee Jung-Hark
Lee Byung-Dong
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Abstract
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This study was carried out to confirm analytical method of residual macrolides in livestock products by LC/MS. 1. Macrolides were analyzed by LC/MS on XTerra C18/ column with 0.1% TFA(trifluoroacetic acid)-methanol in a gradient mode as mobile phase, and that were identified by positive chemical ionization with selective ion monitoring at 50～1000 mass range. 2. Residual macrolides were extracted from tissue with acetonitrile, and the extract is purified with a Sep-pak C18/ cartridge, and elute macrolides with 0.1M methanolic ammonium acetate. 3. The procedure confirms the presence of each macrolide at 50/kg in spiked sample.
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KEYWORD
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Macrolide antibiotics, LC/MS, Livestock products
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