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KMID : 1023520020250030299
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Korean Journal of Veterinary Service
2002 Volume.25 No. 3 p.299 ~ p.308
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Disposition of sulfathiazole in plasma and tissue of broiler chicks following oral administration
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Seo Heyng-Seok
Im Jeong-Cheol
Hur Boo-Hong
Kwon Jung-Taek
Kim Seong-Moon
Chon Hee-Woong
Choi In-Bang
Kim Jin-Shang
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Abstract
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The purposes of this study were to characterize the disposition of sulfathiazole(ST) and to investigate the effects of sodium bicarbonate on the disposition of ST in broiler chicks(2.5～3.0kg). Animals were given ST acutely(10～80mg/kg, PO), and plasma, kidney, muscle, heart, liver and spleen samples were collected and analyzed for ST by high performance liquid chromatography. The plasma and tissue data was consistent with a one-compartment pharmacokinetic model. The drug is rapidly but incompletely(2.5～3.87%) absorbed with peak plasma and tissue levels being achieved within one hour after dosing. The plasma and tissue levels depended on drug dosage, and the descending order in concentration of ST was kidney > plasma > heart > muscle spleen liver from animals sacrificed at one hour after dosing. Moreover, significant positive correlations(r>0.9) existed between plasma and tissue levels of ST. In addition, sodium bicarbonate pretreatment decreased plasma level, indicating that an alkalinization stimulate the excretion of ST. Results of this study suggest that oral application of ST was rapidly absorbed and eliminated, and confirmed that tissue residues of ST can be estimated from plasma drug concentration in broiler chicks.
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KEYWORD
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Sulfathiazole, Broiler chicks, HPLC, Plasma, Alkalinization
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