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KMID : 1023520030260010073
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Korean Journal of Veterinary Service
2003 Volume.26 No. 1 p.73 ~ p.80
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Experimental infection in guinea pig with foot and mouth disease virus
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Abdul Ahad
Rahman Md-Siddiqur
Rahman Md-Mostafizur
Baek Byeong-Kirl
Lee John-Hwa
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Abstract
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In order to obtain information on murine model for foot and mouth disease virus(FMDV) type Asia 1, we studied whether guinea pig was a suitable model for studying FMDV. Apparently healthy 3 months old albino guinea pigs and unweaned 3 days old Swiss albino mice were used for this study. Total of 8 guinea pigs were divided into the infected(n=5) and control(n=3) groups. The incubation period of FMDV in the guinea pigs were roughly 2 days and the viremia persisted for 3 days in the guinea pigs. Mice inoculated with the plasma from control guinea pigs did not show any sign of viremia. The plasma were titrated by virus neutralization test using suckling mice as an indicator host. The mean virus neutralizing antibody titers of infected guinea pig at 3 DPI, 4 DPI and 5 DPI were log10/2.16, log10/ 3.39 and log10/ 3.44, respectively whereas there was no neutralizing antibody titer in control group. The difference between the mortality pattern and mean virus neutralizing antibody titer of infected and that of control group at day 3, 4, 5 were statistically significant(p<0.0l).
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KEYWORD
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Foot and mouth disease, Neutralization test, Bangladesh
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