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KMID : 1023520050280010081
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Korean Journal of Veterinary Service
2005 Volume.28 No. 1 p.81 ~ p.89
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Study on analytical method of residual benzimidazole anthelmintics in meat by LC/MS
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Choi Eun-Young
Seo Heyng-Seok
Baek Gui-Jung
Hur Boo-Hong
Seo Lee-Weon
Joung Dong-Suk
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Abstract
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Recently, mass spectrometry coupled with liquid chromatography (LC/MS) has been a preferred technique for determination of organic compounds in complex matrixes. LC/MS provides a high degree sensitivity and specificity of the compounds of interest. The purpose of this study was to confirm analytical method of residual 6 benzimidazoles (thiabendazole, oxfendazole, mebendazole, albendazole, flubendazole and fenbendazole) in meat by LC/MS. Benzimidazoles were analyzed by LC/MS on XTerra column with 0.01% trifluoroacetic acid-acetonitrile (TFA) in a gradient mode as mobile phase, and that were identified by electrospray ionization with selected ion recording mode at 150-350 amu mass range. Residual benzimidazoles were extracted from tissue with ethylacetate, and elute benzimidazoles with acetonitrile. In the LC/MS analysis of benzimidazoles, signal to noise ratio was showed relatively high in the positive mode and special ion in the quality analysis was determined via and Fragment ions. A spectrum of benzimidazoles was showed from all 6 benzimidazoles
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KEYWORD
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Benzimidazoles, LC/MS, Meat, Electrospray ionization
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