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KMID : 1023520070300040533
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Korean Journal of Veterinary Service
2007 Volume.30 No. 4 p.533 ~ p.538
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Histopathologic and electron microscopic findings of canine malignant melanoma from the lower limb and digit
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Woo Gye-Hyeong
Kim Ha-Young
Park Jung-Won
Park Eun-Jung
Choi Cheong-Up
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Abstract
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A 16-year-old female mixed dog was submitted for examination at the pathology division of national veterinary research and quarantine service (NVRQS). Grossly, white or grayish spherical, multinodular, firm to friable masses were present in the tibiofibula to the pharenge area of the right limb, and dysphagia, breathing difficulties and tachypnea were shown. Various-sized white or grayish black masses were scattered in lungs and diaphragm and one mass was observed in the trachea and in the jejunum, respectively. Histopathologically, the neoplastic cells were composed of polygonal or spindle shaped cells with various sized round to oval nuclei and abundant cytoplasm. These cells formed lobules or nests separated by fine connective tissue and contained little amount of melanin pigments. Melanin pigments were stained dark gray or black with Fontana-Masson method. Melanosomes were also ultrastructurally demonstrable by electron microscopy. Based on above results, the present case was diagnosed as canine malignant melanoma originating from the lower limb and digit.
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KEYWORD
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Malignant melanoma, Melanin, Canine, Digit
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