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KMID : 1023520110340020095
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Korean Journal of Veterinary Service
2011 Volume.34 No. 2 p.95 ~ p.102
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Analysis of complete genome sequence of foot-and-mouth disease (FMD) Asia1 vaccine strain
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Lee Yeo-Joo
Chu Jia-Qi
Lee Seo-Yong
Kim Su-Mi
Lee Kwang-Nyeong
Ko Young-Joon
Lee Hyang-Sim
Cho In-Soo
Nam Seok-Hyun
Park Jong-Hyeon
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Abstract
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Foot-and-mouth disease (FMD) is one of the most infectious diseases affecting cloven-hoofed animals including cattle, sheep, goats, and pigs. Seven serotypes of foot-and-mouth disease virus with multiple subtypes within each serotype have been identified until now. In particular, it has been demonstrated that the outbreak of the serotype Asia1 reported from China, Mongolia and North Korea since 2005 is mostly classified into genetic group V. Though it has been recommended that Asia1 Shamir strain can be used as a high priority vaccine by World References Laboratory for FMD, the complete nucleotide sequences of the strain has not yet been determined. In this study, to be prepared for Asia1 type viruses that may be brought into Korea, the complete genome sequence of this vaccine strain Asia1 Shamir including its 5’ and 3’ non-coding region was identified.
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KEYWORD
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Foot-and-mouth disease, Asia1, Vaccine, Complete sequence
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