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KMID : 1023520110340030235
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Korean Journal of Veterinary Service
2011 Volume.34 No. 3 p.235 ~ p.243
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Effects of Lactobacillus acidophilus on innate immunity
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Kang Shin-Seok
Byeon Hyeon-Seop
Kim Jeong-Tae
Lee Ran
Kang So-Jeong
Jung Ho-Sung
Kang Sung-Ho
Lee Jae-Dong
Kim Dong-Hee
Kang Shin-Kwon
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Abstract
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Probiotics have many effects such as antihypertensive, prevention of cancer, antioxidation, reduction of dermatitis symptoms, improvement of mineral absorption, reduction of allergic symptoms, and decrease of cholesterol, However, the main role of probiotics is that they balance intestinal microbials proportion. L. acidophilus is one of probiotics and microflora in intestine. It has an acidification activity, aroma production, texture formation and probiotics properties. We studied on the roles of L. acidophilus in mice. In this study, body weights of mice were decreased when administration of L. acidophilus (1×1010 CFU) and swimming ability has been raised than a normal group after feeding on L. acidophilus (1×1010 CFU). After taking L. acidophilus (1×1010 CFU), total white cells were increased than a normal group; hemoglobin and thrombocytes were increased. The level of cholesterol and triglyceride were decreased in blood analysis. We knew L. acidophilus is related to innate immune system. We found out the secretion of cationic peptide was increased in the Lysoplate assays as a result of L. acidophilus (1×1010 CFU) administration. Appearance rate of lysozyme was also increased than the normal group on an immunohistochemistry stain. We confirmed L. acidophilus contributes to host health through innate immune system stimulation. L. acidophilus more than 1×1010 CFU are thought to be beneficial for the host health and prevention of intestinal diseases in field condition.
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KEYWORD
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Lactobacillus acidophilus, Probiotics, Lysozyme, Host health, Blood assay
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