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KMID : 1023520140370010051
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Korean Journal of Veterinary Service
2014 Volume.37 No. 1 p.51 ~ p.58
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Antioxidant activity and anti-obesity effect of Coprinus comatus in Zucker rat (fa/fa)
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Lee Soo-Jung
Ko Yeoung-Gyu
Park Hyoung-Joon
Song Yun-O
Jang Sun-Hee
Goo Ae-Jin
Cho Jae-Hyeon
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Abstract
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The aim of the study was to investigate the anti-obesity effect of Coprinus comatus (CC) in high-fat diet-fed Zucker rat (fa/fa). Obesity was induced by feeding on high-fat diet (HFD) containing 60% kcal fat for 10 weeks, in which CC extracts were administrated through the gastrointestinal tract at a concentration of 200 mg/kg BW/day for 10 weeks. The total polyphenol and flavonoid contents of CC extracts were found to be 18.5±1.1 mg of catechin equivalent/g, and 5.24±0.54 mg of quercetin equivalent/g extract, respectively. The DPPH, ABTS, and hydroxyl radical scavenging activities of CC extracts were 15.34 %, 17.25%, and 16.18%, respectively. In animal study, CC administration significantly reduced the body weight, while there were no significant differences in the daily food intake between the HFD-fed Zucker rats and HFD plus CC-fed rats. CC treatment decreased epididymal and perirenal fat weights in HFD-fed Zucker rats. Significant decreases in the levels of triglyceride and total cholesterol in the serum and liver were observed in the CC-treated group compared with HFD-fed Zucker rats.Serum HDL-cholesterol levels in the CC-treated group were increased compared with the HFD-fed groups. Serum AST and ALT activities in the CC group were significantly lower than those of the HFD-fed group. Taken together, these data demonstrated that CC has potential in preventing high-fat diet induced obesity and is a good candidate for an anti-obesity agent.
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KEYWORD
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Coprinus comatus, Zucker rat, HFD-fed obesity, lipid profiles
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