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KMID : 1023520150380020117
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Korean Journal of Veterinary Service
2015 Volume.38 No. 2 p.117 ~ p.125
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Antioxidant activity and hepatic lipids improvement effects of Rubus coreanus in high-fat diet-fed rats
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Lee Soo-Jung
Song Young-Min
Song Yun-O
Chung Min-Sup
Jang Sun-Hee
Won Chung-Kil
Cho Jae-Hyeon
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Abstract
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This study was investigated the effects on the radical scavenging activities and hepatic lipid levels in rats fed a high-fat diet (HFD) by the 70% ethanolic extract from Rubus coreanus. The Rubus coreanus extract (RCE) was administered through the gastrointestinal tract at 150 mg/kg BW/day for 5 weeks (HFD+RCE). Total phenol content was 157.93 mg gallic acid/g in the RCE. Scavenging activities to DPPH, ABTS, an d hydroxyl radicals by RCE significantly increased in a does-dependent manner of 50∼500 g/mL concentration. DPPH and ABTS radical scavenging activities were over the 70% in the 500 g/mL concentration. During the five weeks study, the food efficiency ratio was no significant differences between the HFD and HFD+RCE. Liver weight of HFD+RCE (3.75 g/100 g BW) was significantly decreased compared to those of the HFD. Hepatic triglyceride and total cholesterol levels of HFD+RCE were significantly lower compared to those of the HFD. The hepatic TBARS contents in the HFD+RCE was significantly decreased to the HFD, radical scavenging activity was markedly increased in HFD+RCE as normal group. In histological observation of liver tissues, the hepatocytes of HFD+RCE appeared the reduced aspects on the size and numbers of lipid droplets in cytoplasm compared to the HFD. Our results suggest that RCE could have antioxidant activities and hepatic hypolipidemic effects by its phenolic compounds.
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KEYWORD
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Rubus coreanus, Antioxidant activity, Hepatic lipid profiles
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